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What’s exciting though is that this administration recently signed an executive order directing the agency to speed up the development and approval process for psychedelics.

> this administration recently signed an executive order directing the agency to speed up the development and approval process for psychedelics

Can’t the President directly unschedule it?


Because Trump is in bad need of this shit?

"oh wow, look at my tiny hands, so tiny, hands"

Yup. Not sure which particular stopped-clock struck right within the generally anti-science MAHA movement but I think everybody is happy to take the win.

Ironically enough, the psychedelic field sort of defies some scientific analysis, so could be construed as "anti-science". I've seen some commentary that it's difficult to test. As an example, you can't really do a double blind study with a placebo because it's obvious to everybody who got the drug.

The same could be said for a lot of drugs that have strong side effects, just one difference here is the main "side effects" are something some people consider fun. Though you could still do double-blind for comparing the effectiveness of different psychedelics, e.g comparing LSD to Psilocybin.

Niacin works well as an 'active placebo'.

I’ve seen studies use methylphenidate as well for the “control” group. Relatively harmless, will have some effects and side effects on naive subjects.

just because it's not double blind doesn't mean it's not science though.

like idk, how do you do double blind studies of astronomical phenomena?


Yeah I know. I'm pulling that out as an example.

It's also true that people in the psychedelic world talk about non-reproducible aspects of the trip quite a bit. "Set and setting" and so forth.


> just because it's not double blind doesn't mean it's not science though.

Shhh, non-scientists don't know that.


Double blind studies became a requirement in order to protect the people from the greed of pharmaceutica companies and their natural desire to cut corners in research.

> MAHA

Make America Hallucinogenic Again?


*Happy Again.

They only did it because it lets them beat the "big pharma is stealing from you (not us)" drum.

that feeling of a clock striking right is actually a momentary glint of light pouring through a crack in the cold stone shell that has become encrusted around the hearts of those soaking too often in the type of extreme rhetorical panic which broods a curated and embedded fear similar to the kind that makes children afraid of the bogey man, they feel safer to stay hidden with the fear than to venture out enough to discover it was just a chimney sweep on the distant rooftop and everything is fine outside after all where they soon discover some great adventure or purpose in the richness of the world

Burma Shave

Ironic statement considering the last administration used terms like, "birthing people" and denied the existence of the president's dementia.

Keep the pathetic "pat me on the back" comments to Reddit please.


Do persons not birth?

What is that? I can’t seem to figure out what the use case is vs buying off the shelf?

I think it’s a great project but the communication isn’t clear to me.


https://tinygrad.org/#tinybox

I'm not sure exactly why you would buy through them vs rolling your own if you could afford the equivalent hardware.

I'm a firm supporter of local inference though so good on them for doing something


Lol I get nervous when I see a list of products with full specs but no prices

They have prices. Click on the links in the shipping row.

And..... I was right to be nervous

I’d guess even the index in pi for my phone number would be more digits than the phone number.

So not really a compression scheme.


I’m a dumb question asker and I’m not happy about the guardrails.

Would you believe I’ve asked 20 questions and haven’t talked to fable yet? Every single thing gets rerouted to 4.8.


some static words in AGENTS.md trigger it as well as some mcp servers.

Even using incognito on the web page keeps refusing.

I find it interesting how many people act like inflation doesn’t exist especially with salaries.

If you made 100k in say 2000 the equivalent would be 200k today. If you go by median house price your salary should have doubled since 2015!


Most employers in the US don’t realize this and act like cost of living adjustments are major rewards if they do them at all.

Are they don’t anything useful with AI? I would have figured it could help their operations.

Anyone else have it refuse to answer and switch to 4.8? It won’t let me ask questions about my genetics.

Edit. It just refused an investing question too. Not sure what’s going on.


I never bought into the egg thing. There’s clearly a distinct cell in the center that’s going to divide and grow inside the egg. The egg itself isn’t undergoing mitosis.

I had to go look this up, as I had heard the egg thing my whole life and just accepted it.

It turns out the oocyte is the single cell inside the egg, which for birds is significantly larger than a typical cell. So in that respect, the cell in a bird egg is very large. However, compared to the egg itself, it's tiny. The yolk and whites in the egg are all to provide nutrients as it grows, if fertilized.


The yolk is an energy/vitamin source, not a 'cell'. The division happens outside the yolk.

From Wikipedia:

> The yolk is not living cell material like protoplasm, but largely passive material


One of the fascinating things about biology I think is this - that if the cells of your body were the size of an egg, they'd be way, way too big and you'd probably die.

I also find it interesting that if your spleen were to go prompt critical, it would irradiate you and you'd probably die. That is my favorite fact about nuclear physics.

For sure. You should definitely avoid bioaccumulating fissionable radionuclides in your spleen, not even a tiny amount if you can help it.

What does that even mean? :D

Wouldn't this be true about any organ?


Another fun fact: if your ears were tomatoes, you'd be deaf.

Honestly I don’t have much faith in Apple intelligence when it can’t even search my settings.

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