I have quite some experience with most mainstream dynamic languages, and wouldn't do any large scale application with any of them.

The company I work for, does large scale enterprise consultancy projects.

This means:

- Multiple development sites;

- Some projects have up to 200 developers;

- Usually several megabytes of source code;

- Continuous Integration build systems with automatic unit and integration tests

- Usually distributed architecture

- High performance requirements

No way I would advise anyone to do develop such systems in a dynamic language, let alone in JavaScript.