"Getting back to the facts, there is nothing allowing us to think that depressed people feel better when taking ketamine BECAUSE the number of synapses increases when taking ketamin."
This seems to be a strange use of the word "allowing". I would say that the evidence presents an interesting and testable hypothesis about the role of synaptic connections in depression. The obvious next step would be to find other methods of inducing similar effects on synapses by means other than ketamine and see if they have similar effects on depression.
Out of interest, what do you think might be some of the biological mechanisms associated with chronic depression and how would you seek to investigate them?
I think most people doubt that depression is caused by a single biological mechanism and is most likely a holistic/dynamic problem. I think that's why some doubt the value of pursueing such reductionist hypothesis of depression.
I don't think that depression is down to a single biological mechanism, and there is a big difference between depression due to environment and chronic depression. But saying "holistic/dynamic" is not an explanation, but is more like waving your hands around and saying "woooo" a lot.
This seems to be a strange use of the word "allowing". I would say that the evidence presents an interesting and testable hypothesis about the role of synaptic connections in depression. The obvious next step would be to find other methods of inducing similar effects on synapses by means other than ketamine and see if they have similar effects on depression.
Out of interest, what do you think might be some of the biological mechanisms associated with chronic depression and how would you seek to investigate them?